DOI
10.1007/s12602-022-10037-3
The Effects of Oral Probiotic Supplementation in Postmenopausal Women with Overweight and Obesity: A Systematic Review and Meta-analysis of Randomized Controlled Trials
作者地址
Lanzhou Univ, Evidence Based Social Sci Res Ctr, Hlth Technol Assessment Ctr, Sch Publ Hlth, Lanzhou, Peoples R China
通讯作者
Chengdong Qiao & Kehu Yang
来源期刊
Probiotics Antimicrob Proteins
摘要
Gut microbiota has been identified as a unique endocrine organ linked to the development of cardiovascular disease and other illnesses, especially deteriorated in overweight and obese postmenopausal women. The object of this systematic review and meta-analysis aimed to assess the effects of oral supplementation with probiotics for overweight and obese postmenopausal women. We performed a systematic search for randomized controlled trials (RCTs) from inception to April 2022 in MEDLINE, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov. We also performed a hand search by reviewing reference lists to identify trials. The risk of bias in individual studies was assessed with the Cochrane risk of bias tool for randomized trials (RoB). Two reviewers independently selected studies and collected data. There were 6 studies from 5 RCTs with 281 participants in this systematic review. Compared with the placebo, the probiotics supplementation group had reductions in insulin (MD - 4.20 IU/L (95% CI - 8.11 to - 0.30 IU/L), I-2 = 54%), HOMA-IR (MD - 1.25 (95% CI - 2.49 to - 0.01), I-2 = 50%), and TNF-alpha (MD - 0.12 pg/mL (95% CI - 0.22 to - 0.01 pg/mL), I-2 = 44%). Improvements were also shown in body adiposity and lipid profile, but these effects were nonsignificant. In addition to body adiposity and cardiovascular risk markers, one trial showed the administration of probiotics also had an effect on iron metabolism. In conclusion, probiotics have a potential benefit on glucose metabolism and inflammatory process in overweight and obese postmenopausal women, but this effect is mild. It demonstrates that oral probiotics supplementation can be a complementary treatment for improving the fitness of postmenopausal women with overweight and obesity.
资助信息
This work was supported by the Major Project of the National Social Science Fund of China: Research on the Theoretical System, International Experience and Chinese Path of Evidence-Based Social Science under Grant 19ZDA142
WOS学科分类
Biotechnology & Applied Microbiology
;
Microbiology
WOS关键词
DISEASE RISK-FACTORS
;
BODY-MASS INDEX
;
GUT MICROBIOTA
;
DOUBLE-BLIND
;
CARDIOVASCULAR HEALTH
;
WEIGHT MANAGEMENT
;
ADIPOSE-TISSUE
;
FAT MASS
;
CONSUMPTION
;
METABOLISM
附件
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s12602-022-10037-3.pdf
2.76 MB
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