作者地址
Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu 610041, Sichuan, Peoples R China
摘要
Backgrounds: Pulmonary tuberculosis (PTB) is a major health and economic burden. Accurate PTB detection is an important step to eliminating TB globally. Interferon gamma-induced protein 10 (IP-10) has been reported as a potential diagnostic marker for PTB since 2007. In this study, a meta-analysis approach was used to assess diagnostic value of IP-10 for PTB.
Methods: Web of Science, PubMed, the Cochrane Library, and Embase databases were searched for studies published in English up to February 2019. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), the area under the curve (AUC) and hierarchical summary receiver operating characteristic (HSROC) curve were estimated by the HSROC model and random effect model.
Results: Eighteen studies including 2836 total participants met our inclusion criteria. The pooled sensitivity, specificity, PLR, and NLR of IP-10 for PTB detection were 86, 88%, 7.00, and 0.16, respectively. The pooled DOR was 43.01, indicating a very powerful discriminatory ability of IP-10. The AUC was 0.93 (95% CI: 0.91-0.95), showed the accuracy of IP-10 was good. Meta-regression showed that there was no heterogeneity with respect to TB burden, study design type, age, IP-10 assay method, IP-10 condition and HIV-infection status.
Conclusions: Our results showed that IP-10 is a promising marker for differentiating PTB from non-TB.
资助信息
This work was supported by the National Science Foundation of China (81330016, 81630038, 81771634, 81842011), the National Key R&D Program of China (2017YFA 0104200), the grants from the Ministry of Education of China (IRT0935), the grants from the Science and Technology Bureau of Sichuan Province (2016TD0002), and the grant from the clinical discipline program (Neonatology) from the Ministry of Health of China (1311200003303).
