作者地址
Ningxia Med Univ, Grad Sch, Yinchuan 750004, Ningxia, Peoples R China
摘要
Background. According to relevant clinical research, dietary and circulating antioxidants vitamin A are connected with the risk of breast, cervical, and cancer women. However, there was inconsistency between the findings. We completed this meta-analysis at the right moment to address this contradiction of the problem. Methods. Web of Science, Embase, and PubMed databases were searched using the proposed search strategy and filtered using the inclusion and exclusion criteria as well as the NOS quality score. As of May 2022, low intake or low concentration was used as a control, and odds ratio (OR) or relative risk (RR) and ninety-five percent confidence intervals (95% CI) were extracted for high intake. Stata 12.0 was used to process the data. Results. Our meta-analysis included a total of 49 studies, 29 on breast cancer, 10 on ovarian cancer, and 10 on cervical cancer. There were 38 case-control studies included, with 25,363 cases and 42,281 controls; there were 11 cohort studies included, 1,334,176 individuals were followed up, and finally 9496 obtained cancer. The pooled OR value results were as follows: diet or supplements (OR=0.83, 95% CI 0.76-0.90, I2=56.1%) and serum or plasma (OR=0.96, 95% CI 0.86-1.09, I2=29.5%). Subgroup analyses were performed according to cancer type, diet or supplements, serum or plasma, study type, and geographic regions. Conclusions. In North American and Asian populations, high dietary consumption of vitamin A or supplements decreases the incidence of three cancers in women, with breast and ovarian cancers being more significant. However, high circulating vitamin A concentrations were not significantly connected with the risk of the three malignancies.
资助信息
Our study was supported by the following projects: the 2021 Central-Guided Local Science and Technology Development Fund (ZYYDDFFZZJ-1), the Gansu Key Laboratory of Molecular Diagnosis and Precision Treatment of Surgical Tumors (18JR2RA033), the Key Laboratory of Gastrointestinal Cancer Diagnosis and Treatment of National Health Commission (2019PT320005), the Key Talent Project of Gansu Province of the Organization Department of Gansu Provincial Party Committee (2020RCXM076), and the Guiding Plan for Scientific and Technological Development of Lanzhou (2019-ZD-102).
