Effectiveness of dignity therapy for patients with advanced cancer: A systematic review and meta-analysis of 10 randomized controlled trials
作者地址
Lanzhou Univ, Sch Publ Hlth, Evidence Based Social Sci Res Ctr, Lanzhou 730000, Gansu, Peoples R China
通讯作者
Guanghua Liu; Kehu Yang
来源期刊
DEPRESSION AND ANXIETY
摘要
Background Dignity is a vitally important aspect of the lives of advanced cancer patients. We conducted a systematic review and meta-analysis of the effectiveness of dignity therapy in this patient population. Methods We searched for randomized controlled trials comparing dignity therapy versus standard care for patients with advanced cancer in five comprehensive databases (March 2019), two clinical trial registries and one gray literature database (August 2019). The quality of the studies was assessed using the risk of bias tool recommended by the Cochrane Handbook Version 5.1.0. We used GRADE approach to assess the certainty of evidence. Meta-analysis was performed with RevMan version 5.3. Outcomes of interest included anxiety, depression, dignity-related distress and quality of life (QoL). Results Ten trials evaluating 904 patients (control, 449; experimental, 455) were identified. Six trials included patients with different types of advanced cancer, and four trials included patients with a single advanced cancer (lung cancer [20%], breast cancer [10%], and hepatocellular carcinoma [10%]). Compared with the standard care, dignity therapy decreased the score of anxiety, depression, and dignity-related distress of the advanced cancer patients (SMD = -1.07, 95% CI: [-1.57, -0.58], p < .05; SMD = -1.31, 95% CI: [-1.92, -0.70], p < .05; MD = -7.30, 95% CI: [- 12.04, - 2.56], p < .05). In addition, no significant differences were found in the patient's QoL (p > .05). Conclusion Very low certainty evidence demonstrated that dignity therapy might be a promising treatment, especially in reducing anxiety and depression in advanced cancer patients.
资助信息
China Medical Board Open Project Funding: Tracking and Evaluating Quality (TEQ) of Rural Health Services in NW China: Tool kits for rural clinic quality management and capacity building(17-279); Special Fund for Soft Science in Gansu Province: Study on the Measures to Improve the Quality of Rural Health Services in Gansu Province(18CX1ZA043); Fundamental Research Funds for the Central Universities: Evidence Based Social Science Research (18LZUJBWZX006/2019jbkyjc002)
资助机构
中国医学委员会
;
甘肃省财政厅
;
教育部
;
财政部
WOS学科分类
Psychology, ClinicalPsychiatryPsychology
WOS关键词
TERMINALLY-ILL PATIENTSQUALITY-OF-LIFEPALLIATIVE CAREMETHODOLOGICAL QUALITYREPORTING QUALITYHOSPITAL ANXIETYINTERVENTIONDEPRESSIONDISTRESSEXPERIENCE
附件
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311 Effectiveness of dignity therapy for patients with advancedcancer A systematic review and meta‐analysis of 10randomized controlled trials.pdf
3.66 MB
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