10.1093/trstmh/trab158

The efficacy and safety of intermittent preventive treatment with sulphadoxine-pyrimethamine vs artemisinin-based drugs for malaria: a systematic review and meta-analysis

Xiajing Chua ; Peijing Yane ; Na Zhang ; Nan Chen ; Yang Liu ; Lufang Feng ; Meixuan Li ; Ziyao Zhang ; Qi Wang ; Shizhong Wang

Lanzhou Univ, Evidence Based Social Sci Res Ctr, Sch Publ Hlth, Lanzhou 730000, Peoples R China

Kehu Yang

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

0035-9203

1878-3503

2022-03-13

116

4

298-309

Background Malaria is one of the most serious global problems. The objective of this study is to assess whether intermittent preventive treatment (IPT) using artemisinin-based combination therapies (ACTs) was a promising alternative to IPT with sulphadoxine-pyrimethamine (IPT-SP). Methods We searched the following sources up to 12 August 2020: PubMed, The Cochrane Library, Embase, Web of Science, CNKI, CBM, VIP and WanFang Database from inception. The randomized controlled trials comparing SP with ACTs for malaria were included. Data were pooled using Stata.14 software. We performed subgroup analysis based on the different types of ACTs groups and participants. Results A total of 13 studies comprising 5180 people were included. The meta-analysis showed that ACTs had the lower risk of number of any parasitemia (RR=0.46; 95% CI 0.22 to 0.96, p=0.039; I-2=90.50%, p<0.001), early treatment failure (RR=0.17; 95% CI 0.06 to 0.48, pI(2)=66.60%, p=0.011) and late treatment failure (RR=0.34; 95% CI 0.13 to 0.92, pI(2)=87.80%, p<0.001) compared with SP. There was no significant difference in adequate clinical response, average hemoglobin and adverse neonatal outcomes. Conclusion Combinations with ACTs appear promising as suitable alternatives for IPT-SP.

artemisinin-based combination therapies, malaria, meta-analysis, sulfadoxine-pyrimethamine, sulfadoxinepyrimethamine-artesunate, systematic review

the National Social Science Fundof China [no. 19ZDA142]

国家自然基金委

https://academic.oup.com/trstmh/article/116/4/298/6397199?login=true

英语

中国

循证医学 ; 循证社会学

SCIE

Public, Environmental & Occupational HealthTropical Medicine

Author Keywordsartemisinin-based combination therapiesmalariameta-analysissulfadoxine-pyrimethaminesulfadoxine-pyrimethamine-artesunatesystematic review ; Keywords PlusUNCOMPLICATED FALCIPARUM-MALARIALOW-BIRTH-WEIGHTDIHYDROARTEMISININ-PIPERAQUINEMETHODOLOGICAL QUALITYARTESUNATEANTIMALARIALCOMBINATIONPREGNANCYTHERAPYSULFADOXINE/PYRIMETHAMINE

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