DOI
10.1097/MD.0000000000019719
Association between hepatitis B virus infection and risk of osteoporosis: a systematic review and meta-analysis: A protocol for systematic review
作者地址
Department of Orthopaedics, Affiliated Hospital of Northwest Minzu University.
摘要
Background: The potential association between hepatitis B virus (HBV) infection and development of osteoporosis has drawn significant attention from clinicians and researchers in recent years due to the increasing prevalence of HBV infection. This study aims to perform a systematic review and meta-analysis of the literature to show whether HBV infection is associated with an increased risk of osteoporosis.
Methods: Case-control, cohort, and cross-sectional studies that report the incidence of osteoporosis, osteoporotic fracture, osteopenia, and bone mineral density level in populations with HBV infection will be selected. Four databases from their inception to October 2019 will be searched. All data were assessed and extracted by 2 authors independently. The Newcastle-Ottawa scale and (Agency for Healthcare Research and Quality) Agency for Healthcare Research and Quality checklist will be used to assess the quality of the selected studies. Stata 15.1 (Stata Corp, College Station, TX) will be used to conduct meta-analysis.
Result: The results of this systemic review and meta-analysis will be submitted to a recognized journal for publication.
Conclusion: This systemic review and meta-analysis will determine whether HBV infection is associated with an increased risk of osteoporosis. We hope this review can provide a reliable evidence.
Registration: PROSPERO (registration number CRD42020140522).
资助信息
National Natural Science Foundation of China (81860864); the Laboratory of Intelligent Medical Engineering of Gansu Province (GSXZYZH2018001)
资助机构
国家自然科学基金委员会
;
甘肃省发改委
WOS学科分类
Medicine
;
General & Internal
WOS关键词
LIVER-CIRRHOSIS
;
QUALITY
;
WOMEN
;
DISEASE
附件
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