10.2217/fon-2020-0822

Relationship between antidepressive agents and incidence risk of breast cancer: systematic review and meta-analysis

Rui Li ; Xiuxia Li ; Peijing Yan ; Zhitong Bing ; Liujiao Cao ; Xu Hui ; Jing Li ; Xingrong Liu ; Kehu Yang

Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, 730000, China

Xingrong Liu; Kehu Yang

Future Oncology

1479-6694

1744-8301

2020-11-01

17

9

1105-1124

Purpose: This study aimed to review the association between antidepressive agent (AD) use and the incidence risk of breast cancer. Methods: CBM, WOS, Embase, PubMed and Cochrane Library were systematically searched in July 2019. The methodological quality of the studies was assessed through the Newcastle–Ottawa Scale. Results: We included 19 studies from six countries or regions with relationships between breast cancer and ADs. Subgroup analysis showed no significant association in nested case–control or case–control studies; however, cohort studies revealed a significant association (odds ratio = 1.11; 95% CI: 1.04–1.17). Conclusions: This meta-analysis indicates that breast cancer was not associated with the use of ADs when considering all types of studies, but an association was observed if we considered cohort studies.

antidepressive agents breast cancer depressionl incidence meta-analysis systematic review

the Fundamental Research Funds for the Central Universities: Evidence Based Social Science Research (grant no. 2019jbkyjc002, lzujbky-2019-ct02 and lzujbky-2020-kb20)

财政部和教育部

https://www.tandfonline.com/doi/full/10.2217/fon-2020-0822?scroll=top&needAccess=true

英文

中国

循证医学

SCIE

Oncology

PLASMA PROLACTIN CONCENTRATIONS ; SEROTONIN REUPTAKE INHIBITORS ; MEDICATION USE ; REPORTING QUALITY ; DEPRESSION ; TAMOXIFEN ; HORMONE ; ASSOCIATION ; GROWTH ; WOMEN

8

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