DOI
10.1080/10641955.2019.1593445
The association between calcium supplement and preeclampsia and gestational hypertension: a systematic review and meta-analysis of randomized trials
作者地址
Department of Obstetrics and Gynecology, The First Clinical Medical College , Lanzhou University, Gansu Provincial Hospital , Lanzhou , China
通讯作者
Xuehong Zhang; Xiaotong Sun
来源期刊
Hypertension in pregnancy
摘要
Objectives: The purpose of this study is to investigate whether calcium supplement with or without other drugs could reduce the risk of preeclampsia and gestational hypertension based on existed evidence, and to clarify whether there is discrepant effect among different population and using different dose.
Methods: PubMed, Cochrane library, and EMBASE database were searched. Two authors independently screened all records and extracted data. The meta-analysis was performed to calculate risk ratios and 95% CIs using random-effects models.
Results: 27 studies, with 28 492 pregnant women were included. The results showed calcium supplement was associated with lower incidence of preeclampsia (RR 0.51, 95% CI: 0.40 to 0.64) and gestational hypertension (RR 0.70, 95% CI: 0.60 to 0.82). Sub-analyses revealed high-dose (1.2-2 g/day), moderate-dose (0.6-1.2 g/day), and low-dose (<0.6 g/day) of calcium supplement could reduce the risk of preeclampsia. For gestational hypertension, only high dose and moderate dose groups were associated with reducing the risk of gestational hypertension. However, we could draw a conclusion which does group was the most protective, as we were unable to directly compare the effects of different doses.
Conclusions: This study indicated calcium supplementation might decrease the risk of preeclampsia and gestational hypertension. And results of subgroups analyses enhanced our confidence to the protective effect of calcium supplementation. However, further studies with direct comparison of different dose of calcium supplementation are needed to explore the ideal dose of calcium supplementation to prevent preeclampsia and gestational hypertension.
WOS学科分类
Obstetrics & Gynecology
;
Physiology
;
Peripheral Vascular Disease
WOS关键词
BLOOD-PRESSURE
;
PREGNANCY
;
PREVENTION
;
RISK
;
DISORDERS
;
WOMEN
附件
-
463 The association between calcium supplement and preeclampsia and gestational hypertension a systematic review and meta-analysis of randomized trials.pdf
1.66 MB
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
