DOI
10.1016/j.smrv.2019.101215
Insomnia and risk of mortality from all-cause, cardiovascular disease, and cancer: Systematic review and meta-analysis of prospective cohort studies
作者地址
Evidence Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, 730000, China
通讯作者
Kehu Yang
来源期刊
Sleep medicine reviews
ISSN
1087-0792
EISSN
1532-2955
出版日期
2019-12-11
卷号
48
摘要
Growing evidence indicates that insomnia may be associated with mortality. However, these findings have been inconsistent. We systematically searched MEDLINE and EMBASE to identify prospective cohort studies that assessed the association between insomnia disorder/individual insomnia symptoms and the risk of mortality among adults aged ≥18 yrs. We addressed this association using summary hazard ratios (HRs) and 95% confidence intervals (CIs) calculated using random-effects meta-analysis, and the GRADE approach to rate the certainty of evidence. Twenty-nine cohorts including 1,598,628 individuals (55.3% men; mean age 63.7 yrs old) with a median follow-up duration of 10.5 yrs proved eligible. Difficulty falling asleep (DFA) and non-restorative sleep (NRS) were associated with an increased risk of all-cause mortality (DFA: HR = 1.13, 95%CI 1.03 to 1.23, p = 0.009, moderate certainty; NRS: HR = 1.23, 95%CI 1.07 to 1.42, p = 0.003, high certainty) and cardiovascular disease mortality (DFA: 1.20, 95%CI: 1.01, 1.43; p = 0.04, moderate certainty; NRS: HR = 1.48, 95%CI 1.06 to 2.06, p = 0.02, moderate certainty). Convincing associations between DFA and all-cause mortality were restricted to the mid to older-aged population (moderate credibility). Insomnia disorder, difficulty maintaining sleep, and early morning awakening proved to be unassociated with all-cause and cardiovascular disease mortality. No insomnia symptoms proved to be associated with cancer-related mortality.
资助信息
the Central Universities - Research on Evidence-Based Social Science (16LZUJBWTD013)
资助机构
财政部和教育部
语种
英文
国家
学科领域
收录类别
SCIE
WOS学科分类
Clinical Neurology ; Neurosciences
WOS关键词
C-REACTIVE PROTEIN ; 12-YEAR FOLLOW-UP ; SLEEP DURATION ; OLDER-ADULTS ; MYOCARDIAL-INFARCTION ; HEALTH OUTCOMES ; DISTURBANCES ; POPULATION ; SYMPTOMS ; COMPLAINTS
被引频次(WOS)
120
研究类型
Meta分析
附件
  • 478 Insomnia and risk of mortality from all-cause, cardiovascular disease, and cancer Systematic review and meta-analysis of prospective cohort studies.pdf
    1.25 MB

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