Introduction. Intimate partner violence (IPV) is a complex phenomenon composed of multiple micro and macro socio structural elements. It has become a public health priority. The aim of the study was to identify IPV-prevention interventions directed towards the Latino and Hispanic-American population through a systematic review, following the Joanna Briggs Institute guidelines. Methodology. Studies were extracted from PubMed, EBSCO, PsycINFO, Web of Sciences, Scopus and Scielo using a specific search strategy for each database. Articles on IPV-prevention in the Latino and/or Hispanic-American population aged between 13 and 24 years, published in English or Spanish and until July 2020 were included. After eliminating duplicates, a total of 1,031 studies were reviewed by title and abstract, 31 were full-text peer-reviewed, and six studies were included in the evidence synthesis. Results. Four studies presented a medium level of quality and two a high-quality level, according to the Joanna Briggs evaluation tools. Four interventions were implemented in the USA and two in Mexico. Regarding the characteristics of the total sample of the six interventions, the age range was 13 to 23 years, and all addressed both sexes. The six interventions were implemented in educational institutions. The shortest intervention was a four-hour session and the longest was 18-sessions long. Five of the six interventions were theory-based, including Social Learning Theory, Cognitive Social Theory, Theatre of the Oppressed, and the Social Development Model. Significant results were obtained in the following domains: decreasing the acceptance of violence; greater self-efficacy to resolve non-violent conflicts and greater intentions not to act violently; increased perception and attitudes towards violence; increased knowledge about violence; less acceptance of aggression women-to-men; and an increase in help-seeking. Discussion and conclusions. Compared to the number of available interventions that do not specifically address race or socio-cultural background criteria, there are few IPV-prevention interventions addressing adolescents and young adults, or culturally ad hoc interventions for Latin and Hispanic-American populations. Worthy of note was the short duration of interventions in relation to the expected outcome based on the dependent variables, as behavioral change depends on them. Interventions to prevent IPV may be promising when implemented in the educational context, including students, teachers and staff, with participatory community-based approaches and considering the uniqueness of the socio-cultural and structural context that shapes violence against women. The adaptation of such interventions to similar contexts through systematic processes contributes to knowledge transfer and the improvement of innovations.