Individuals born with Trisomy 21 may be more susceptible to experiencing nutrition-related conditions and diseases throughout their lifespan. Seven studies conducted outside of Canada that investigated the impact of nutrition interventions in individuals of different ages (mostly children and youth) born with Trisomy 21 reported mixed results. Furthermore, Canadian clinical nutrition practice guidelines for the provision of care to individuals born with Trisomy 21 tend to be general in nature and may be based on a body of evidence that was not representative of this population. There is a need for well-designed inclusive nutrition research studies to determine the nutritional needs of individuals born with Trisomy 21 and to better understand how to provide person-centred nutrition and healthcare services that achieve nutrition and health equity for these individuals and improve their overall nutritional status and health.