Objective: To assess the overall effect of pharmacist-involved medication therapy management (MTM) on patient outcomes and to interpret the assessment for a general population. Methods: Many small studies have documented the influence the pharmacist's role within MTM for specific populations. However, not many studies have documented the impact of the importance of a pharmacist in MTM overall in general populations. A stronger indicator of improved patient outcomes with a pharmacist-led MTM could lead to larger studies and better health care policy in the future. A literature search of published studies (hospital and community settings) was performed in Medline (via PubMed), the International Pharmaceutical Abstracts, and Embase. Studies were also identified from the references in these articles and in reviews. For a study to be included in this meta-analysis, it must have a pharmacist-involved medication intervention. The included studies were published no earlier than January 2009 in developed countries. All studies with less than 50 participants or a follow-up period less than 16 weeks were excluded. The recommendations of Cochrane Collaboration and the Quality of Reporting of Meta-analyses guidelines were also implemented. Results: Preliminary data analysis suggests a significant improvement in patient outcomes with a pharmacist-involved MTM. When observing strictly patient adherence in three previously selected trials, the pharmacist intervention had a 7% greater patient adherence versus the control intervention. Conclusion: NA (research in progress)