BACKGROUND: The aim was to assess the efficacy of antimicrobial photodynamic therapy(aPDT) in the treatment of aggressive periodontitis (AgP). METHODS: The addressed focused question was 'Is aPDT effective in the treatment of AgP?'MEDLINE/PubMed, EMBASE, Scopus, ISI Web of knowledge and Google-Scholar databases were searched from 1977 till May 2015 using combinations of the following key words: antimicrobial; photochemotherapy; photodynamic therapy; photosensitizing agents; AgP; scaling and root-planing (SRP). Reviews, case reports, commentaries, and articles published in languages other than English were excluded. RESULTS: Seven studies were included. In 5 studies aPDT was performed as an adjunct to SRP. Laserwavelengths and duration of irradiation ranged between