At first glance, implementing evidence-based treatments for ethnically diverse youths may seem to raise some concerns. Do manual-based treatments work for the diverse youths whom we see in our communities? Should clinicians only use culturally specific treatments? Unfortunately, the literature is not definitive. Several studies have found that tailoring interventions for specific populations can increase their effectiveness, whereas others have found that cultural adaptations of an intervention may actually dilute the effectiveness of the original treatment even though retention is improved. What seems to be important is to strike a balance between fidelity to evidence-based treatment and culturally informed care.