In the context of ever-increasing humanitarian needs worldwide, anticipatory action is being recognised as one of main the ways in which predictable shocks can be prevented from turning into crises, reducing both the impacts and the costs. Anticipatory action is a critical approach, bridging the work of disaster risk reduction and humanitarian response, and showing great promise as a modality for nexus programming (for example, linking humanitarian to development). While a scale-up of anticipatory action is much needed, it also requires a truly decolonial and feminist approach that supports communities to uphold their rights. To meet this vision, Oxfam has laid out four interconnected fundamental principles for all partners and stakeholders involved in scaling up anticipatory action to use: Adopting these principles in the scale-up of anticipatory action will unlock some of the key challenges of the approach. The principles acknowledge the sectoral trends that call for sector-wide transformation in line with key principles, but overall, they are designed to ensure that anticipatory action is effective and fit for purpose. This paper calls for governments, communities, humanitarian, climate, peace and development practitioners, and the private sector to adopt the proposed four interconnected fundamentals in the scale-up of anticipatory action and support at-risk communities to uphold their rights. This principled approach to embedding anticipatory action into policy, practice, and legal frameworks is required to maximise the potential of anticipatory action and prevent predictable shocks from becoming crises.

COVID-19 is not only associated with substantial acute liver and kidney injuries, but also with an elevated risk of post-acute sequelae involving the kidney and liver system. We aimed to investigate whether COVID-19 exposure increases the long-term risk of kidney and liver disease, and what are the magnitudes of these associations. We searched PubMed, Embase, Web of Science, , and the Living Overview of the Evidence COVID-19 Repository for cohort studies estimating the association between COVID-19 and kidney and liver outcomes. Random-effects meta-analyses were performed to combine the results of the included studies. We assessed the certainty of the evidence using the Grading of Recommendations Assessment, Development and Evaluation approach. Fifteen cohort studies with more than 32 million participants were included in the systematic review COVID-19 was associated with a 35% greater risk of kidney diseases (10 more per 1000 persons; low certainty evidence) and 54% greater risk of liver disease (3 more per 1000 persons; low certainty evidence). The absolute increases due to COVID-19 for acute kidney injury, chronic kidney disease, and liver test abnormality were 3, 8, and 3 per 1000 persons, respectively. Subgroup analyses found no differences between different type of kidney and liver diseases. The findings provide further evidence for the association between COVID-19 and incident kidney and liver conditions. The absolute magnitude of the effect of COVID-19 on kidney and liver outcomes was, however, relatively small.

Postoperative gastrointestinal disorder (POGD) was a common complication after surgery under anesthesia. Strategies in combination with Traditional Chinese Medicine and Western medicine showed some distinct effects but standardized clinical practice guidelines were not available. Thus, a multidisciplinary expert team from various professional bodies including the Perioperative and Anesthesia Professional Committees of the Chinese Association of Integrative Medicine (CAIM), jointly with Gansu Province Clinical Research Center of Integrative Anesthesiology/Anesthesia and Pain Medical Center of Gansu Provincial Hospital of Traditional Chinese Medicine and WHO Collaborating Center for Guideline Implementation and Knowledge Translation/Chinese Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) Center/Gansu Provincial Center for Medical Guideline Industry Technology/Evidence-based Medicine Center of Lanzhou University, was established to develop evidence-based guidelines. Clinical questions (7 background and 12 clinical questions) were identified through literature reviews and expert consensus meetings. Based on systematic reviews/meta-analyses, evidence quality was analyzed and the advantages and disadvantages of interventional measures were weighed with input from patients' preferences. Finally, 20 recommendations were developed through the Delphi-based consensus meetings. These recommendations included disease definitions, etiologies, pathogenesis, syndrome differentiation, diagnosis, and perioperative prevention and treatment.

The authors identify tasks that the People's Liberation Army (PLA) would likely be assigned by Chinese leaders to achieve strategic goals both in peacetime competition with the United States and in a hypothetical low-intensity conflict. The authors then analyze potential vulnerabilities in the PLA's execution of those tasks and how the United States could leverage those vulnerabilities to disrupt China's strategic goals, focusing on the potential for peacetime competition to erupt into a broader low-intensity conflict featuring smaller, indirect, or hybrid confrontations that span the world. The authors expand on a comprehensive list of potential PLA missions developed in prior research and explore vulnerabilities in the PLA's execution of the specific tasks required to achieve Beijing's strategic objectives. Across these missions and tasks, they identify five sets of vulnerabilities that, if disrupted, could affect Beijing's ability to achieve its goals: fears of domestic instability after PLA actions, risk of escalating conflict, harm to China's reputation, the PLA's limited ability to support partner states, and the PLA's limited ability to project power. These vulnerabilities provide a sense of the potential pressure points that the PLA could face in accomplishing its objectives. Options for the United States to leverage these pressure points include deterring harmful PLA actions by shaping perceptions of how those actions might affect China's interests, exploiting the consequences of PLA actions to deter Beijing from repeating similar actions, and exploiting PLA weaknesses in power projection and partner support to weaken confidence in the PLA and discourage similar operations.

Over the past decade, China has upended the world of development assistance, rapidly becoming the world's largest bilateral lender by channeling large sums of money into the developing world. As China's economic engagement in the developing world has grown, so too have U.S. and allied concerns that China is leveraging development assistance to assert Chinese influence, weaken the United States' relative position, and achieve Beijing's broader national security interests. In this report, the authors conduct a net assessment of U.S. and Chinese development assistance and cooperation. The authors describe each country's differing approaches to economic engagement with developing countries and conduct a data-driven comparison to identify strategic asymmetries that might present opportunities for the United States to better compete with China for relationships and influence in the developing world. The assessment reveals that Chinese economic engagement in the developing world should not be conceptualized as aid or assistance; this mischaracterization has potentially led to an overreliance on U.S. development tools as a primary response. Moreover, despite evidence of the short-term benefits that China might gain from its development financing, it is not clear whether these benefits are sustainable or effective over the long term when compared with the U.S. approach. Nevertheless, China's efforts — its heavy emphasis on energy and infrastructure projects, its approach to working through elite actors in developing countries, and its willing embrace of greater risk and reduced transparency — create challenges and opportunities for the United States as it looks to compete with China in the developing world.

Background The health effects of dietary fats are a controversial issue on which experts and authoritative organizations have often disagreed. Care providers, guideline developers, policy-makers, and researchers use systematic reviews to advise patients and members of the public on optimal dietary habits, and to formulate public health recommendations and policies. Existing reviews, however, have serious limitations that impede optimal dietary fat recommendations, such as a lack of focus on outcomes important to people, substantial risk of bias (RoB) issues, ignoring absolute estimates of effects together with comprehensive assessments of the certainty of the estimates for all outcomes.Objective We therefore propose a methodologically innovative systematic review using direct and indirect evidence on diet and food-based fats (i.e., reduction or replacement of saturated fat with monounsaturated or polyunsaturated fat, or carbohydrates or protein) and the risk of important health outcomes.Methods We will collaborate with an experienced research librarian to search MEDLINE, EMBASE, CINAHL, and the Cochrane Database of Systematic Reviews (CDSR) for randomized clinical trials (RCTs) addressing saturated fat and our health outcomes of interest. In duplicate, we will screen, extract results from primary studies, assess their RoB, conduct de novo meta-analyses and/or network meta-analysis, assess the impact of missing outcome data on meta-analyses, present absolute effect estimates, and assess the certainty of evidence for each outcome using the GRADE contextualized approach. Our work will inform recommendations on saturated fat based on international standards for reporting systematic reviews and guidelines.Conclusion Our systematic review and meta-analysis will provide the most comprehensive and rigorous summary of the evidence addressing the relationship between saturated fat modification for people-important health outcomes. The evidence from this review will be used to inform public health nutrition guidelines.

OBJECTIVE To compare the effects of treatments for coronavirus disease 2019 (covid-19). DESIGN Living systematic review and network meta-analysis. DATA SOURCES US Centers for Disease Control and Prevention COVID-19 Research Articles Downloadable Database, which includes 25 electronic databases and six additional Chinese databases to 20 July 2020. STUDY SELECTION Randomised clinical trials in which people with suspected, probable, or confirmed covid-19 were randomised to drug treatment or to standard care or placebo. Pairs of reviewers independently screened potentially eligible articles. METHODS After duplicate data abstraction, a bayesian random effects network meta-analysis was conducted. Risk of bias of the included studies was assessed using a modification of the Cochrane risk of bias 2.0 tool, and the certainty of the evidence using the grading of recommendations assessment, development and evaluation (GRADE) approach. For each outcome, interventions were classified in groups from the most to the least beneficial or harmful following GRADE guidance. RESULTS 23 randomised controlled trials were included in the analysis performed on 26 June 2020. The certainty of the evidence for most comparisons was very low because of risk of bias (lack of blinding) and serious imprecision. Glucocorticoids were the only intervention with evidence for a reduction in death compared with standard care (risk difference 37 fewer per 1000 patients, 95% credible interval 63 fewer to 11 fewer, moderate certainty) and mechanical ventilation (31 fewer per 1000 patients, 47 fewer to 9 fewer, moderate certainty). These estimates are based on direct evidence; network estimates for glucocorticoids compared with standard care were less precise because of network heterogeneity. Three drugs might reduce symptom duration compared with standard care: hydroxychloroquine (mean difference -4.5 days, low certainty), remdesivir (-2.6 days, moderate certainty), and lopinavir-ritonavir (-1.2 days, low certainty). Hydroxychloroquine might increase the risk of adverse events compared with the other interventions, and remdesivir probably does not substantially increase the risk of adverse effects leading to drug discontinuation. No other interventions included enough patients to meaningfully interpret adverse effects leading to drug discontinuation. CONCLUSION Glucocorticoids probably reduce mortality and mechanical ventilation in patients with covid-19 compared with standard care. The effectiveness of most interventions is uncertain because most of the randomised controlled trials so far have been small and have important study limitations.

Introduction The adaptation of guidelines is an increasingly used methodology for the efficient development of contextualised recommendations. Nevertheless, there is no specific reporting guidance. The essential Reporting Items of Practice Guidelines in Healthcare (RIGHT) statement could be useful for reporting adapted guidelines, but it does not address all the important aspects of the adaptation process. The objective of our project is to develop an extension of the RIGHT statement for the reporting of adapted guidelines (RIGHT-Ad@pt Checklist). Methods and analysis To develop the RIGHT-Ad@pt Checklist, we will use a multistep process that includes: (1) establishment of a Working Group; (2) generation of an initial checklist based on the RIGHT statement; (3) optimisation of the checklist (an initial assessment of adapted guidelines, semistructured interviews, a Delphi consensus survey, an external review by guideline developers and users and a final assessment of adapted guidelines); and (4) approval of the final checklist. At each step of the process, we will calculate absolute frequencies and proportions, use content analysis to summarise and draw conclusions, discuss the results, draft a report and refine the checklist. Ethics and dissemination We have obtained a waiver of approval from the Clinical Research Ethics Committee at the Hospital de la Santa Creu i Sant Pau (Barcelona, Spain). We will disseminate the RIGHT-Ad@pt Checklist by publishing into a peer-reviewed journal, presenting to relevant stakeholders and translating into different languages. We will continuously seek feedback from stakeholders, surveil new relevant evidence and, if necessary, update the checklist. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

The aim of this study is to improve understanding of how biological resource conservation concerns can be better incorporated into projects and programs that primarily address the objective of rural development rather than environmental conservation. A multi-disciplinary study team was assembled and six background papers produced, along with the main overview paper. The six papers were on: 1) measuring biodiversity, predicting impacts, and monitoring change; 2) integrated pest management and biodiversity conservation; 3) biodiversity conservation in agricultural landscapes in Britain: relevant issues for developing countries; 4) reconciling biodiversity and development issues in practice; the search for a win-win situation in Ghana's coastal wetlands; 5) strategies for biodiversity conservation: examples from Tanzania; and 6) participatory initiatives in biodiversity conservation: lessons from experience. A study was also made of World Bank policies and procedures relating to biodiversity management and rural development together with three portfolio reviews. These findings were incorporated into this paper. This paper argues that bioresources and people's livelihood systems are intricately interrelated, and opportunities for intervention for development purposes must start from good understanding of different people's access to and use and management of these resources, and also the incentives, constraints, and institutional factors governing the process.

This paper disaggregates the term "biodiversity" into components (landscapes, ecosystems, communities, species/populations, and genes) and attributes (structure, composition, and function). It then disaggrgates "logging" by detailing the vast range of activities subsumed under the term including variation of logging intensities, logging methods, collateral damage, and silvicultural approaches. Using the richness present in both terms, a framework for considering the impacts of logging and other forest management activities on the various components and attributes of biodiversity is presented. This framework is, in turn, used to evaluate the extensive literature covering different studies of logging in tropical forests. This paper does not conclude with uncritical support for sustainable forest managmement of timber as a conservation strategy. Such an endorsement is unwarranted given widespread illegal logging in the tropics, widespread frontier logging and logging of areas of high priority for biodiversity protection, the persistence of poor logging practices despite substantial efforts in research and training, and the generally slow rate at which most loggers are transforming themselves from timber exploiters into forest managers. Rather the authors assert, from a biodiversity maintenance perspective, that natural forest management is preferable to virtually all land-use practices other than complete protection.

The study addresses the importance of wildlife to people, and as a resource of nutritional, economic, and socio-cultural values, and examines the complexities of hunting in tropical forests. It also expresses that today, such hunting is rarely sustainable, because of declining forest areas, which decreases wildlife populations; because of changes among human populations in the tropical forests, who have increasingly become more sedentary; because of cultural changes, where social taboos against hunting certain species are breaking down, and systems of traditional hunting territories are disappearing; and, because environmental economic changes, prod the commercialization of wildlife hunting in these areas. The study explores the multifaceted, and complex problem of hunting, suggesting solutions must be area specific, based on detailed knowledge of hunting patterns, ecology, and local socio-cultural conditions. Recommendations include: establishment of national networks to manage protected, and extractive reserves areas, to supply subsistence needs to local hunting communities; establish land uses to support protected/extractive reserves areas in partnership with local communities; enact, comply, and enforce regulations to prevent exploitation by timber companies' workers; and, encourage participatory approaches among non-governmental organizations, academic institutions, and the international community at large.

As the world is urbanizing, many cities are grappling with a population that is growing rapidly, thereby increasing demand for land and housing. This pressure on land and housing markets often is exacerbated by inappropriate or inadequate policies. The result is a supply of well-located land and housing that falls well short of demand and the proliferation of poorly serviced informal settlements, many of which are located far from jobs, city services and amenities. This paper discusses the major policy levers local leaders may have at their disposal to improve access to land and housing and thereby change the landscape of cities for the better. It discusses common obstacles administrative, political, and financial and options for overcoming them. In particular, the report: (1) takes a fresh look at some traditional mechanisms such as land regulation, property taxation, and public-private partnerships; (2) reintroduces some innovative land tools community land trusts, guided development, transfer of development rights, land pooling/readjustment, and land sharing that may have a place in cities' arsenal of responses; and (3) suggests ways to garner the political support that will be needed to move forward with programs of reform.