Anisotropic polaritons in low-symmetry crystals allow for subwavelength confinement and directional routing of light. The most extreme form of such anisotropy arises at the topological transition between elliptical and hyperbolic dispersion, where the isofrequency contours collapse into parallel lines and polaritons propagate in a diffractionless, beam-like fashion. This canalization regime has previously been accessed through twisted heterostructures or engineered metasurfaces. Here we show that intrinsic canalization can be achieved without any fabrication or structuring by exploiting the intrinsic elliptical-to-hyperbolic transition in the van der Waals crystal MoOCl2 at room temperature. Using near-field imaging, we directly visualize plasmon-polariton canalization emerging at the low-loss Drude crossing point along the [010] crystal axis. Owing to the moderate slope of the Drude permittivity, the resulting polaritons remain highly directional across a broad spectral window. This weak dispersion also enables robust thickness-dependent tuning, and we demonstrate, both experimentally and theoretically, that the canalization wavelength can be adjusted by more than 1 μm simply by varying the flake thickness. This work brings canalized polariton propagation into the 4.5–6 μm range, beyond the frequency limits of phonon–polariton platforms and overlapping with important molecular vibrations, opening new opportunities for mid-infrared nanophotonics and sensing.