Optimizing field cropping practices to improve nitrogen use efficiency is imperative to promote intensive and sustainable wheat production. As a cultivation method commonly adopted in arid and semi-arid regions globally, the ridge-furrow mulching system (RFMS) is capable of efficiently harvesting rainfall, reduce evaporation losses, enhancing soil moisture levels in the root zone, and boosting crop productivity. However, the combined effects of varying ridge-furrow ratios (RD), ridge heights (RH), and nitrogen application rates (RN) on nitrogen fertilizer bias productivity (PFPN) under the influence of climatic conditions, soil types, and field management practices remain poorly understood due to a lack of systematic evaluation. This study conducted a meta-analysis of 462 comparative datasets from 98 research projects to reveal the interactive effects of RFMS and nitrogen fertilizer across climatic gradients. The results showed that RH, RD, and RN increased by 23.78%, 22.37%, and 23.07% respectively (p < 0.05), with the most significant enhancement of PFPN being demonstrated by RH. The most significant improvement in PFPN was observed when RD = 1:1, R < 10 cm, and RN > 200 kg center dot hm(-2), with PFPN increasing by 27.7%, 29.50%, and 29.32% respectively (p < 0.05). Climatic and soil physico-chemical factors and field management practices are the key factors influencing the RFMS. When average annual evapotranspiration (AE) < 1000, RN > 200 has the best effect on nitrogen utilization efficiency, while under the condition of AE > 1500, RN < 100 is more effective. In terms of mulching strategy, full mulching of ridges and furrows is recommended in areas with severe drought and low temperatures, while mulching only ridges or furrows is more appropriate in areas with relatively mild climate. The present study provides a scientific basis for the optimal design of ridge-furrow mulching configuration and nitrogen application level. This is achieved by considering climatic conditions, soil fertility, and field management in agro-ecosystems in arid and semi-arid areas.