In arid regions, soil salinization and inefficient water use are major challenges to sustainable agricultural development. Optimizing subsurface drainage system layouts is critical for improving saline soil reclamation efficiency. This study conducted field experiments from 2023 to 2024 to evaluate the effects of varying subsurface drainage configurations-specifically, burial depths (1.0-1.5 m) and pipe spacings (20-40 m)-on drainage and salt removal efficiency in silty loam soils of southern Xinjiang, aiming to develop an optimized scheme balancing water conservation and desalination. Five treatments (A1-A5) were established to measure evaporation, drainage, and salt discharge during both spring and winter irrigation. These variables were analyzed using a water balance model and multifactorial ANOVA to quantify the interactive effects of drainage depth and spacing. The results indicated that treatment A5 (1.5 m depth, 20 m spacing) outperformed all the others in terms of both the drainage-to-irrigation ratio (R-d/i) and the drainage salt efficiency coefficient (DSEC), with a two-year average R-d/i of 32.35% across two spring and two winter irrigation events, and a mean DSEC of 3.28 kgm(-3). The 1.5 m burial depth significantly improved salt leaching efficiency by increasing the salt control volume and reducing capillary rise. The main effect of burial depth on both R-d/i and DSEC was highly significant (p < 0.01), whereas the effect of spacing was not statistically significant (p > 0.05). Although the limited experimental duration and the use of a single soil type may affect the generalizability of the findings, the recommended configuration (1.5 m burial depth, 20 m spacing) shows strong potential for broader application in silty loam regions of southern Xinjiang and provides technical support for subsurface drainage projects aimed at reclaiming saline soils in arid regions.