This study investigates the influence of rear setback geometry and fa & ccedil;ade design parameters on microclimatic conditions, indoor thermal comfort, and energy performance in multi-story residential buildings in hot arid climates, addressing the growing need for climate-responsive design in regions with extreme temperatures and high solar radiation. Despite increasing interest in sustainable strategies, the combined effects of urban geometry and building envelope design remain underexplored in these environments. A coupled simulation framework was developed, integrating ENVI-met for outdoor microclimate modeling with Design Builder and EnergyPlus for dynamic building performance analysis. A total of 270 simulation scenarios were examined, combining three rear setback aspect ratios (1.5, 1.87, and 2.25), three window-to-wall ratios (10%, 20%, and 30%), three glazing types (single-, double-, and triple-pane), and two wall insulation states, using customized weather files derived from microclimate simulations. Global sensitivity analysis using rank regression and multivariate adaptive regression splines identified the glazing type as the most influential parameter (sensitivity index approximate to 0.99), especially for upper floors. At the same time, higher aspect ratios reduced peak Physiological Equivalent Temperature (PET) by up to 5 degrees C and decreased upper-floor cooling loads by 37%, albeit with a 9.3% increase in ground-floor cooling demand. Larger window-to-wall ratios lowered lighting energy consumption by up to 35% but had minimal impact on cooling loads, whereas wall insulation reduced annual cooling demand by up to 29,441 kWh. The results emphasize that integrating urban morphology with optimized fa & ccedil;ade components, particularly high-performance glazing and suitable aspect ratios, can significantly improve thermal comfort and reduce cooling energy consumption in hot arid residential contexts.