The United Arab Emirates (UAE), with its arid climate and rapidly growing population, faces increasing pressure on freshwater resources. Integrating Small Modular Reactors (SMRs) with desalination infrastructure offers a viable, low-carbon pathway for sustainable water production. This study evaluates technically feasible and regionally relevant integration scenarios by analyzing representative case studies of existing desalination plants across the UAE. Using the Desalination Economic Evaluation Program (DEEP) tool of the International Atomic Energy Agency (IAEA), the economic viability of the coupling of the various SMR types with the existing desalination plants in the UAE was evaluated for this study, specifically the desalination plants based on reverse osmosis (RO), distillation process alone, and in conjunction with one another. Sensitivity analyses were conducted to evaluate the influence of key parameters such as discount rate, interest rate, salinity, capacity factor, and desalination technology selection on project viability. The results indicate that coupling high-efficiency SMRs with large-scale seawater reverse osmosis (SWRO) plants, such as the Taweelah facility, yields the competitive water cost, while thermal desalination technologies remain favorable in hybrid mode when integrated with high-temperature SMRs like the high-temperature reactor pebble-bed module (HTR-PM). This work provides a decision-making framework for future nuclear-desalination integration projects tailored to the UAE's energy and water security objectives.