Central Asia, characterized by complex topography and arid to semi-arid climate, is heavily influenced by the westerlies, which transport water vapor and dust aerosols, creating a highly variable climate system in this region. Thick loess deposits in central Asia serve as key archives offering valuable insights into the historical evolution of climate, environmental changes, and dust dynamics. However, the absence of a robust chronological framework has impeded efforts to retrieve the full paleoclimatic information from central Asian loess. In this study, we performed detailed chronological analyses on three thick loess-paleosol profiles in southern Tajikistan, employing a combination of luminescence dating and magnetic susceptibility stratigraphy. We applied the single-aliquot regenerative-dose (SAR) protocol for medium-grained (38-63 mu m) quartz grains and the post-infrared infrared stimulated luminescence (pIR200IR290) protocol on polymineral grains. These results provide a reliable age constraint for the Tajikistan loess deposited during the Late Pleistocene, revealing a highly synchronous pattern with widespread contemporaneous loess-paleosol cycles and deep-sea oxygen isotope records. Our chronological analyses indicate that depositional hiatuses occurring at the top of paleosol horizons represent a common and significant issue in central Asian loess sequences, with important implications for their strati-graphic division and correlation. Using the Bacon age-depth model, we further reconstructed variations in magnetic susceptibility (chi), dust accumulation rate (DAR), and medium grain size for the Late Pleistocene loess S1-L1 from the SRN (Shahrinav) and KMD (Karamayidan) profiles, covering approximately 80-20 ka. The observed decreasing gradients in loess thicknesses and DAR from west to east indicate the primary dust source of deserts in the western central Asia. Moreover, these data reveal the persistent regional climatic variability throughout the last glacial-interglacial cycle, driven by the topographic transition from the sloping foreland to the rugged mountains in Tajikistan. The wetter conditions during interglacial periods likely intensified regional moisture disparities, whereas drier glacial conditions amplified differences in dust accumulation rates and mineral grain sizes. These results highlight the necessity of accounting for regional variability when interpreting paleoclimatic data from loess in central Asia.