In China's Loess Plateau, sustainable agricultural end products are affected by an insufficiency of water resources. Rising crop water use efficiency (WUE) through field management pattern improvement is a crucial plan of action to address this issue. However, there is no agreement among researchers on the most appropriate field management practices regarding WUE, which requires further integrated quantitative analysis. We conducted a meta-analysis by quantifying the effect of agricultural practices surrounding nitrogen (N) fertilizer management. The two experimental cultivars were Yunhan-20410 and Yunhan-618. The subplots included nitrogen 0 kgha-1 (N0), 90 kgha-1 (N90), 180 kgha-1 (N180), 210 kgha-1 (N210), and 240 kgha-1 (N240). Our results show that higher N rates (up to N210) enhanced water consumption during the node-flowering and flowering-maturity time periods. YH-618 showed higher water use during the sowing-greening and node-flowering periods but decreased use during the greening-node and flowering-maturity periods compared to YH-20410. The N210 treatment under YH-618 maximized water use efficiency (WUE). Increased N rates (N180-N210) decreased covering temperatures (Tmax, Tmin, Taver) during flowering, increasing the level of grain filling. Spike numbers rose with N application, with an off-peak at N210 for strong-gluten wheat. The 1000-grain weight was at first enhanced but decreased at the far end of N180-N210. YH-618 with N210 achieved a harvest index (HI) similar to that of YH-20410 with N180, while excessive N (N240) or water reduced the HI. Dry matter accumulation increased up to N210, resulting in earlier stabilization. Soil water consumption from wintering to jointing was strongly correlated with pre-flowering dry matter biological process and yield, while jointing-flowering water use was linked to post-flowering dry matter and spike numbers. Post-flowering dry matter accumulation was critical for yield, whereas spike numbers positively impacted yield but negatively affected 1000-grain weight. In conclusion, our results provide evidence for determining suitable integrated agricultural establishment strategies to ensure efficient water use and sustainable production in the Loess Plateau region.