Soil moisture (SM) profoundly influences global ecosystem services and climate change, creating the broad needs for SM management. However, existing single-scale studies have limited representativeness and overlook the spatial non-stationarity, while treating regions with diverse SM conditions as a whole may obscure interactions between environment and different SM levels. Therefore, we expanded the study scale both horizontally and vertically and established an "SM security" framework, which classifies SM conditions based on their impacts on evapotranspiration, vegetation growth, and soil quality. SM was measured to 500 cm depth across the Yellow River Basin (YRB) (795,000 km(2)) and categorized into three security zones including "wet zone" that SM >= 80 % * field capacity (FC), "transitional zone" that permanent wilting point (PWP) < SM < 80 % * FC, and "dry zone" that SM <= PWP. In the YRB, the transitional zone was predominant (61.58 %), followed by wet (20.24 %) and dry (18.17 %) zones. In relatively stable layers (110-500 cm), the wet zone expanded with depth (17.04 % to 25.86 %) while dry zone contracted (20.76 % to 14.99 %). The mean relative SM (dimensionless) and available SM storage, indicating relative soil saturation and vegetation water availability, were 0.84 and 32.14 cm, respectively. Considering spatial non-stationarity, environmental drivers shaping the SM security pattern were: slope in wet zone, vegetation in dry zone, and clay content, vegetation, and slope in transitional zone, with notable coupling among these factors. These findings help characterizing SM security and developing targeted SM management measures in the YRB and similar regions worldwide.