The Huangshui River Basin is located in the transition zone between the Loess Plateau and the Qinghai-Tibet Plateau, characterized by a fragile hydrological and ecological environment. Groundwater serves as a vital water source for local economic development and human livelihood. With the acceleration of urbanisation and climate change, groundwater resources face challenges such as pollution and over-exploitation. This study employs an improved DRASTIC model, tailored to the characteristics of the groundwater system in the Huangshui River Valley of the upper Yellow River, to integrate groundwater resources, groundwater environment, and ecological environment systems. Improving the DRASTIC model for groundwater vulnerability assessment. A two-tiered evaluation system with nine indicator parameters was proposed, including six groundwater quality vulnerability indicators and five groundwater quantity vulnerability indicators. Fuzzy analytic hierarchy process and entropy weight method were used to determine the weights, and Geographic Information System (GIS) spatial analysis was employed to evaluate groundwater vulnerability in the Huangshui River basin in 2006 and 2021. The results indicate that the proportion of areas with high groundwater quality vulnerability increased from 10.7% in 2006 to 31.57% in 2021, while the proportion of areas with high groundwater quantity vulnerability decreased from 22.33% to 14.02%. Overall, groundwater quality vulnerability in the Huangshui River basin is increasing, while groundwater quantity vulnerability is decreasing. Based on the evaluation results of water quality and quantity vulnerability, protection zoning maps for water quality and quantity were compiled, and preventive measures and recommendations for water quality and quantity protection zones were proposed. Human activities have a significant impact on groundwater vulnerability, with land use types and groundwater extraction coefficients having the highest weights. This study provides a scientific basis for the protection and sustainable use of groundwater in the Huangshui River basin.