Camelina is a drought-resistant medicinal oil plant. There is a need for a deeper understanding of its nutrition in arid and semi-arid regions. Therefore, this research aimed to investigate the effect of iron (Fe) and zinc (Zn) on Camelina's yield and physiological traits in water deficit. Different Fe (FeSO4) and Zn (ZnSO4) concentrations (water spray as control, 4 and 8 g l(-1)) were applied by the foliar method at the beginning of leaf development and flowering stages in two environments: well-watered as control (WW) and water deficit or stop irrigation from flowering till maturity (WD) in crop years 2018 and 2019 in Kermanshah, west of Iran. The average Camelina seed, oil, and protein yields in WW were 1100, 394, and 176 kg ha(-1), respectively. Meanwhile, the corresponding traits in WD were 869, 267, and 170 kg ha(-1). The foliar treatment increased them by 17, 25, and 47% in WW and 15, 22, and 32% in WD. Foliar treatments caused a significant increase (p < 0.05) in proline, phenolics, and soluble carbohydrates concentration, as well as the activity of antioxidant enzymes in the leaf and unsaturated fatty acids of oil. Under WD, the highest oil percentage (34.3%) and yield (352 kg ha(-1)) was obtained by applying Fe at 4 g l(-1). Erucic acid in oil was below 5%, and WD reduced it. The evidence from this study suggests that Fe and Zn foliar treatment mitigates the adverse effects of WD on seed and protein yield, oil yield quantity and quality, and antioxidant capacity in Camelina. [GRAPHICS]