The production of rainfed crops in arid regions is an extremely difficult task, especially without tillage. In southern Kazakhstan, in 2020-2021, the approbation of various nutrition regimes for winter wheat grown in conditions of no-tillage rainfed lands has been studied. The effect of different doses and terms of application of growth stimulators, micronutrients, bio-fertilizers and mineral fertilizers, as well as their economic efficiency, was studied in ten variables. The use of a combination of growth stimulators and microfertilizers produced the highest grain yield and was the most cost-effective. The greatest value of the nominal net profit of 223.25 euro and 244.10 euro from one hectare was provided and calculated with the recommended target grain yield of 2.0 t/ha dose of mineral fertilizers, respectively; however, the production cost of one ton of grain in these treatments was also highest. Further research is continuing with a wider range and combination of amendments and various crops in a rainfed no-till winter wheat farm in southern Kazakhstan.