survHE: Survival Analysis for Health Economic Evaluation and Cost-Effectiveness Modeling

2020
Survival analysis features heavily as an important part of health economic evaluation, an increasingly important component of medical research. In this setting, it is important to estimate the mean time to the survival endpoint using limited information (typically from randomized trials) and thus it is useful to consider parametric survival models. In this paper, we review the features of the R package survHE, specifically designed to wrap several tools to perform survival analysis for economic evaluation. In particular, survHE embeds both a standard, frequentist analysis (through the R package flexsurv) and a Bayesian approach, based on Hamiltonian Monte Carlo (via the R package rstan) or integrated nested Laplace approximation (with the R package INLA). Using this composite approach, we obtain maximum flexibility and are able to pre-compile a wide range of parametric models, with a view of simplifying the modelers' work and allowing them to move away from non-optimal work flows, including spreadsheets (e.g., Microsoft Excel).
JOURNAL OF STATISTICAL SOFTWARE
页码:1-47|卷号:95|期号:14
ISSN:1548-7660
收录类型
SSCI
发表日期
2020
学科领域
循证社会科学-方法
国家
英国
语种
英语
DOI
10.18637/jss.v095.i14
其他关键词
EXPECTED VALUE; MONTE-CARLO; EXTRAPOLATION; INFORMATION; SAMPLE
资助机构
Mapi ICON
资助信息
The author wishes to thank Peter Konings, William Browne, Geoff Holmes and Andrea Berardi for providing comments or help in writing part of the original code in survHE. I would also like to thank two anonymous reviewers for their helpful comments and suggestions. This work has been partially supported by a research grant sponsored at University College London by Mapi ICON, a consultancy company working in the area of health economic evaluation.
被引频次(WOS)
4
被引更新日期
2022-01
来源机构
University of London University College London
关键词
survival analysis health economic evaluation probabilistic sensitivity analysis R