Short-term efficacy of non-pharmacological interventions for global population with elevated blood pressure: A network meta-analysis

Tang, WX (通讯作者),China Pharmaceut Univ, Ctr Pharmacoecon & Outcomes Res, Nanjing, Peoples R China.;Malone, DC (通讯作者),Univ Utah, Coll Pharm, Dept Pharmacotherapy, Salt Lake City, UT 84112 USA.;Tang, WX (通讯作者),China Pharmaceut Univ, Sch Int Pharmaceut Business, Dept Publ Affairs Management, Nanjing, Peoples R China.
2023-1-13
Background: This study aims to compare the potential short-term effects of non-pharmacological interventions (NPIs) on prehypertensive people, and provide evidence for intervention models with potential in future community-based management.Methods: In this Bayesian network meta-analysis, Pubmed, Embase, and Web of science were screened up to 16 October 2021. Prehypertensive patients (systolic blood pressure, SBP 120-139 mmHg/diastolic blood pressure, DBP 80-89 mmHg) with a follow-up period longer than 4 weeks were targeted. Sixteen NPIs were identified during the scope review and categorized into five groups. Reduction in SBP and DBP was selected as outcome variables and the effect sizes were compared using consistency models among interventions and intervention groups. Grade approach was used to assess the certainty of evidence.Results: Thirty-nine studies with 8,279 participants were included. For SBP, strengthen exercises were the most advantageous intervention group when compared with usual care (mean difference = -6.02 mmHg, 95% CI -8.16 to -3.87), and combination exercise, isometric exercise, and aerobic exercise were the three most effective specific interventions. For DBP, relaxation was the most advantageous intervention group when compared with usual care (mean difference = -4.99 mmHg, 95% CI -7.03 to -2.96), and acupuncture, meditation, and combination exercise were the three most effective specific interventions. No inconsistency was found between indirect and direct evidence. However, heterogeneity was detected in some studies.Conclusion: NPIs can bring short-term BP reduction benefits for prehypertensive patients, especially exercise and relaxation. NPIs could potentially be included in community-based disease management for prehypertensive population once long-term real-world effectiveness and cost-effectiveness are proven.
FRONTIERS IN PUBLIC HEALTH
卷号:10
收录类别:SCIE
语种
英语
来源机构
China Pharmaceutical University; Shandong University; Utah System of Higher Education; University of Utah; China Pharmaceutical University
资助机构
National Natural Science Foundation of China(National Natural Science Foundation of China (NSFC))
资助信息
This work was supported by General Program of National Natural Science Foundation of China (72174207).
被引频次(WOS)
0
被引频次(其他)
0
180天使用计数
5
2013以来使用计数
5
EISSN
2296-2565
出版年
2023-1-13
DOI
10.3389/fpubh.2022.1051581
WOS学科分类
Public, Environmental & Occupational Health
学科领域
循证公共卫生
关键词
Bayesian network meta-analysis prehypertension non-pharmacological intervention chronic disease management blood pressure reduction