Societal grand challenges are increasingly attracting the attention of both entrepreneurship and international business scholars. While entrepreneurship focuses on the opportunities that emerge and need for bold and innovative solutions, international business research emphasizes the global reach of the challenges and role of multinational enterprises. Although both conversations are insightful, we argue that examining one without the other gives an incomplete picture on how to address grand challenges. In this paper, we conduct a systematic review of the conversation on grand challenges in the international business and entrepreneurship literature. Upon synthesizing the results, we create an integrated framework and research agenda for viewing grand challenges through an international entrepreneurial lens.