Efficacy of COVID-19 vaccines by race and ethnicity

Mohammadi, M (通讯作者),Gerash Univ Med Sci, Cellular & Mol Res Ctr, Gerash, Iran.
2022-7
Objectives: Vaccine uptake amongst ethnic minority populations has been persistently lower, which may be because of socio-economic factors such as health literacy and health insurance status. This review aimed to assess to what extent COVID-19 clinical trials have considered the impact of race and ethnicity on COVID-19 vaccine safety and efficacy. Study design: This was a systematic review. Methods: Data regarding ethnicity in COVID-19 vaccine clinical trials were systematically reviewed ac-cording to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines in this sys-tematic review, which ran from inception until June 2021. Three international databases, PubMed, Scopus and Web of Science, were used to conduct systematic article searches. Only two studies reported vaccine efficacy among ethnic minority groups. Results: The efficacy of the mRNA-1273 vaccine was confirmed to be 95% in Caucasians and 97.5% in 'people of colour' in a study by Baden et al. In another study by Polack et al., BNT162b2 mRNA vaccine efficacy was reported to be 95.2% in Caucasians, 100% in Afro-Caribbean or African Americans, 94.2% in Hispanic or Latinx and 95.4% in non-Hispanic, non-Latinx people. Conclusions: Given the highly differing effect of COVID-19 on the Afro-Caribbean, Hispanic and South Asian populations, it is imperative for COVID-19 vaccine clinical trials to thoroughly assess the safety and efficacy of vaccines in different ethnicities and, if necessary, develop ethnicity-specific protocols, which can minimise the disproportionate effect of COVID-19 on ethnic minority populations. (c) 2022 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.
PUBLIC HEALTH
卷号:208|页码:14-17
ISSN:0033-3506|收录类别:SCIE
语种
英语
来源机构
Kermanshah University of Medical Sciences; Coventry University; Kermanshah University of Medical Sciences; University of Leicester
资助机构
Kermanshah University of Medical Sciences (IR)
资助信息
This study was funded by Deputy for Research and Technology, Kermanshah University of Medical Sciences (IR) (3011574). This deputy has no role in the study process.
被引频次(WOS)
1
被引频次(其他)
1
180天使用计数
7
2013以来使用计数
8
EISSN
1476-5616
出版年
2022-7
DOI
10.1016/j.puhe.2022.04.009
WOS学科分类
Public, Environmental & Occupational Health
学科领域
循证公共卫生
关键词
Efficacy COVID-19 Vaccine Race Ethnicity Review