Objective: This systematic review aimed to identify the information needs and preferences of individuals with CVD from underserved populations.Methods: Five databases were searched from data inception to February 2022. Pilot and case report studies, non -peer-reviewed literature, and studies published in a language other than English, Portuguese, or Spanish were excluded. Structured and thematic analysis of all included studies were performed. The Critical Appraisal Skills Program and the Downs and Black Checklist were used to assess the quality of the qualitative and quantitative studies, respectively.Results: Of 35,698 initial records, 19 studies were included, most in observational design and classified as fair quality. Underserved populations - women, people living in rural areas, ethnic minority groups, older people, and those with low socioeconomic status - presented unique needs in four main groups, with some similarities across them: information about CVD, primary and secondary prevention of CVD, CVD management, and health care, policies and practices. Across the studies there was a lack of standardization on how individuals' needs were assessed and reported.Conclusion: Underserved populations with CVD have unique information needs and preferences that should be address during their care.Practical implication: Information from this study may assist health care professionals with the development of comprehensive strategies to improve their provision of care for specific CVD patient groups.