Suicide is a major public health issue, and a leading cause of death in the United States. Caregivers of young children with or at-risk for disabilities and developmental delays may experience significant life stressors that increase their risk for suicidal thoughts and behaviors. Early childhood special education (ECSE) home visitors may be in a prime position to notice and intervene in these situations but may lack the training and confidence to do so. This article outlines evidence-based strategies for identifying and responding to possible suicidal thoughts and behaviors in the context of ECSE home visiting.