An one-factor copula mixed model for joint meta-analysis of multiple diagnostic tests

Nikoloulopoulos, AK (通讯作者),Univ East Anglia, Sch Comp Sci, Norwich NR4 7TJ, Norfolk, England.
2022-7
As meta-analysis of multiple diagnostic tests impacts clinical decision making and patient health, there is an increasing body of research in models and methods for meta-analysis of studies comparing multiple diagnostic tests. The application of the existingmodels to compare the accuracy of three or more tests suffers from the curse of multi-dimensionality, that is, either the number of model parameters increases rapidly or high dimensional integration is required. To overcome these issues in joint meta-analysis of studies comparing T > 2 diagnostic tests in a multiple tests design with a gold standard, we propose a model that assumes the true positives and true negatives for each test are conditionally independent and binomially distributed given the 2T-variate latent vector of sensitivities and specificities. For the random effects distribution, we employ a one-factor copula that provides tail dependence or tail asymmetry. Maximum likelihood estimation of the model is straightforward as the derivation of the likelihood requires bi-dimensional instead of 2T-dimensional integration. Our methodology is demonstrated with an extensive simulation study and an application example that determines which is the best test for the diagnosis of rheumatoid arthritis.
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY
卷号:185|期号:3|页码:1398-1423
ISSN:0964-1998|收录类别:SCIE
语种
英语
来源机构
University of East Anglia
资助机构
Research and Specialist Computing Support service at the University of East Anglia
资助信息
The authors thank the Editor, Professor James Carpenter, the Associate Editor and the referees for comments leading to a substantially improved presentation. The simulations presented in this paper were carried out on the High Performance Computing Cluster supported by the Research and Specialist Computing Support service at the University of East Anglia.
被引频次(WOS)
0
被引频次(其他)
0
180天使用计数
3
2013以来使用计数
5
EISSN
1467-985X
出版年
2022-7
DOI
10.1111/rssa.12838
学科领域
循证社会科学-综合
关键词
diagnostic tests factor copulas mixed models multivariate meta-analysis sensitivity/specificity summary receiver operating characteristic curves
WOS学科分类
Social Sciences, Mathematical Methods Statistics & Probability