Abstract

Objective To assess the reporting and methodological quality of COVID-19 systematic reviews, and to analyze trends and gaps in the quality, clinical topics, author countries, and populations of the reviews using an evidence mapping approach.

Study design and setting A structured search for systematic reviews concerning COVID-19 was performed using PubMed, Embase, Cochrane Library, Campbell Library, Web of Science, CBM, WanFang Data, CNKI, and CQVIP from inception until June 2020. The quality of each review was assessed using the Assessment of Multiple Systematic Reviews 2 (AMSTAR 2) checklist and the Preferred Reporting ltems for Systematic Reviews and Meta-Analyses (PRISMA) checklist.

Results In total, 243 systematic reviews met the inclusion criteria, over 50% of which (128, 52.7%) were from 14 developing countries, with China contributing the most reviews (76,31.3%). In terms of methodological quality of the studies, 30 (12.3%) were of moderate quality, 63 (25.9%) were of low quality, and 150 (61.7%) were of critically low quality. In terms of reporting quality, the median (interquartile range) PRISMA score was 14 (10-18). Regarding the topics of the reviews, 24 (9.9%) focused on the prevalence of COVID-19,69 (28.4%) focused on the clinical manifestations, 30 (12.3%) focused onetiology, 43 (17.7%) focused on diagnosis, 65 (26.7%) focused on treatment, 104 (42.8%) focused onprognosis, and 25 (10.3%) focused on prevention. These studies mainly focused on general patients with COV/D-19 (161, 66.3%), followed by children (22, 9.1%) and pregnant patients (18, 7.4%).

Conclusion This study systematically evaluated the methodological and reporting quality of systematic reviews of COVID-19, summarizing and analyzing trends in their clinical topics, author countries, and study populations.

Keywords COVID-19; Evidence mapping; Gap map; Methodological quality; Reporting quality; Systematic review.

Li Y, Cao L, Zhang Z, Hou L, Qin Y, Hui X, Li J, Zhao H, Cui G, Cui X, Li R, Lin Q, Li X, Yang K. Reporting and methodological quality of COVID-19 systematic reviews needs to be improved: an evidence mapping. J Clin Epidemiol. 2021 Jul; 135: 17-28. doi: 10.1016/j.jclinepi.2021.02.021. Epub 2021 Feb 28. PMID: 33657455; PMCID: PMC8313077.