Escape rooms are being increasingly employed as an educational approach within health pro-fessions education. Given the rapid increase in their application, investigators have adopted diverse evaluation methods, many of which utilise ad-hoc instruments. To inform future evalu-ation methods and the adoption of validated evaluation instruments, a systematic review is planned. This protocol outlines the steps of this review, which will collate and synthesise the evidence related to the evaluation and efficacy of educational escape rooms within health pro-fessions education. A search, applying terms for escape rooms, healthcare professionals and evaluation, will be conducted using multiple databases. Studies will be screened against eligibility criteria and all eligible studies will be quality assessed using a validated tool. Data will be narratively synthesised.