This article presents a new strategy for reviewing large, multidisciplinary academic literatures: a multi-method comprehensive review (MCR). We present this approach and demonstrate its use by the NGO Knowledge Collective, which aims to aggregate knowledge on NGOs in international development. We explain the process by which scholars can identify, analyze, and synthesize a population of hundreds or thousands of articles. MCRs facilitate cross-disciplinary synthesis, systematically identify gaps in a literature, and can create data for further scholarly use. The main drawback is the significant resources needed to manage the volume of text to review, although such obstacles may be mitigated through advances in big data methodologies over time.