Background: Most significant change (MSC) analysis is an evaluative method used to supplement outcome and impact program evaluations. MSC stories provide mini-narratives contextualizing the effect a program had on an individual. The Clinical Scholars program evaluation team used MSC to explore learner-centric leadership out-comes of the Clinical Scholars leadership training program.Purpose of the research: To identify thematic outcomes of trainees during the three years of their leadership training in the Clinical Scholars program.Results: We identified three central thematic areas of most significant change: (1) leadership in practice, (2) self-awareness, and (3) equity, diversity, and inclusion. Other present themes included stakeholder engagement, effective leadership, collaboration, impact, expanded influence, innovation, networking, community engage-ment, evidence-based, implementation science, organizational development, hope, and advocating within or-ganizations, teams, and the community. A total of 25 mid-and advanced-career level participants represented a diverse array of disciplines within the healthcare sector.Conclusions: MSC stories represented leaders' individual and team growth due to participating in the Clinical Scholars program. Results confirmed fidelity of program implementation to the original program goals, as outlined in the grant proposal. They highlighted three critical areas of development for this cohort of Fellows.